ASSOCIATE PROFESSOR OF GENERAL AND MEDICAL Physics CHAIR
Phone: +375 17 342-27-22
Fax: +375 17 299-51-35
E-mail: zorin@bsu.by, vpzorin@mail.ru
- General Physics
New types of photosensitizers have been developed that are highly effective in PDT treatment of cancer and other diseases. Models have been developed to analyze the distribution of porphyrin photosensitizers in the body. The possibility of using different types of nanocarriers for controlled changes in the pharmacokinetics of photosensitizers during photodynamic therapy is shown.
He was a scientific supervisor of more than 40 projects implemented within the framework of international and state scientific programs, programs of the Ministry of Development of the Republic of Belarus, 8 projects of the BRFFI, including joint projects with scientists from France, Russia, Ukraine, and India. According to the results of the research, more than 300 scientific papers were published, including more than 100 articles in peer-reviewed journals and foreign publications, and three patents were obtained for applications for inventions. The results of the research work were implemented at BSU, BSUIR, RSPC DOGI.
He was the scientific supervisor of 4 dissertations for the degree of Candidate of Biological Sciences and 3 dissertations for the degree of Doctor of Philosophy at the Henri Poincare University (Nancy, France).
Awards
- Gratitude of the BSU Rector.
- Certificates and Honorary certificates of BSU, Faculty of Physics of BSU, Physical Society of Belarus, BRFFI.
| 1977 | Graduated from Belarusian State University |
| 1980 | Completed postgraduate studies at the Department of Biophysics of the Faculty of Physics of Belarusian State University |
| 1983 | Defended PhD thesis in Biological Sciences at the Institute of Photobiology of the Academy of Sciences of the BSSR |
| 1980-1990 | Worked at the Department of Biophysics of Belarusian State University as a junior researcher, researcher, senior researcher |
| Since 1990 | Head of the Research Institute of Biophysics and Biotechnology |
| 1989-1990 | Trained at the University of Padua (Italy) |
| 2003 | Trained at the Alexis Vatran Cancer Center (Nancy, France) |
- Garrier J., Reshetov V., Zorin V., Guillemin F., Bezdetnaya L. Contrasting facets of nanoparticles-based phototherapy: photo-damage and photo-regeneration. In: Photodynamic Therapy: New research. Ed. Mohamed Lotfy Taha Elsaie: Nova Science Publishers, Inc. – 2013. P. 3-38.
- Далидович А.А., Марченко Л.Н.. Федулов А.С., Трухачева Т.В., Кривоносов В.В., Зорина Т.Е., Зорин В.П. Фотодинамическая терапия Фотолоном®миопической макулопатии. – Минск: Парадокс, 2012. – 224 с.
- Reshetov V.A., Zorina T.E., Bolotine L.N., Zorin V.P. Kinetic determinants of liposomal photosensitizers//Ж.«Фотодинамическая терапия и фотодиагностика», спец. выпуск. – 2015. – С. 14.
- Yankovsky I., Yakovets I., Bolotine L., Zorin V.P. Aiteration of meta-tetra(hydroxyphenyl)chlorine biodistribution by β-cyclodextrin derivatives// Ж.«Фотодинамическая терапия и фотодиагностика», спец. выпуск. – 2015. – С. 14.
- Zorina T.E., Yankovsky I.V., Kravchenko I.E., Shman T.V., Belevtsev M.V., Zorin V.P. Evaluation of Phototoxicity and Cytotoxicity for Chlorin e6 Ester Derivatives and Liposomal Forms//Biophysics. – 2015. – V. 60, № 5. – P. 759-766.
- Зорина Т.Е., Янковский И.В., Кравченко И.Е., Шман Т.В., Белевцев М.В., Зорин В.П. Оценка фото- и цитотоксичности этерифицированных производных хлорина е6 и их липосомальных форм//Биофизика. – 2015. – Т. 60, вып. 5. – С. 922-930.
- Зорина Т.Е., Янковский И.В., Кравченко И.Е., Шман Т.В., Белевцев М.В., Зорин В.П. Цитотоксичность и фотосенсибилизирующие свойства этерифицированных производных хлорина е6 и их липосомальных форм//Ж. «Фотодинамическая терапия и фотодиагностика», спец. выпуск. – 2015. – С. 15.
- Хлудеев И.И., Козырь Л.А., Зорина Т.Е., Зорин В.П. pH-зависимые изменения механизмов транспорта хлорина е6 и его производных в крови // Бюллетень экспериментальной биологии и медицины. – 2015. –Т. 160, № 8, С. 170-175
- Хлудеев И.И., Зорин В.П. Ультрафильтрационный метод оценки параметров связывания производных хлорина е6 с сывороточным альбумином//Вестник БГУ, Серия 1. – 2015. – № 2. – С. 19-24.
- Яковец И.В., Янковский И.В., Болотина Л.Н., Зорин В.П. Особенности спектральных характеристик мета-тетра(гидроксифенил)хлорина в биологических системах//Вестник БГУ, Серия 1. – 2015. – № 2. – С. 39-45.
- Garrier J., Reshetov V., Gräfe S., Guillemin F., Zorin V., Bezdetnaya L. Factors affecting the selectivity of nanoparticle-based photoinduced damage in free and xenografted chorioallantoïc membrane model//J. Drug Target, April 2014, V. 22, №. 3 , P. 220-231.
- Reshetov V.A., Lassalle H.-P., François A., Dumas D., Hupont S., Gräfe S., Filipe V., Jiskoot W., Guillemin F., Zorin V., Bezdetnaya L. Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo//International J. on Nanomedicine. – 2013. – №8. – P. 3817-3831
- Хлудеев И.И., Терех А.С., Смирнов А.В., Дик Т.А., Зорин В.П. Спекл-оптический конроль микрогемоциркуляции при различных типах воздействия на васкулярную систему // Журнал прикладной спектроскопии. – 2013. – Т. 80, № 2. – С. 305-310.
- Reshetov V., Zorin V., Siupa A., D’Hallewin M.-A., Guillemin F., Bezdetnaya L. Interaction of liposomal formulations of meta-tetra(hydroxyphenyl)chlorin (temoporfin) with serum proteins: protein binding and liposome destruction // Photochem. Photobiol.–2012. – V.88. – P. 1256-1264.