HEAD OF IMMUNOLOGY chair
Academic degree and rank: Doctor in Medical Sciences, Professor
Position: Head of Immunology Chair
Phone: +375 17 243-00-07
Address: Minsk, 23/1 Dolgobrodskaya str., room 414
E-mail: zafranskaya@gmail.com
Disciplines taught
- Module Medicine-1 “Immunology”.
- Immunobiology and immunopathology.
- Autoimmune pathology
- Infectious immunology
- Immunodiagnostics. Clinical immunology.
- Problems of clinical and environmental immunology
- Aspects of applied immunology
- Immunology of the infectious process
- Mechanisms of autoimmune processes
- General immunology
Key results and projects
- Over the decades of her research and pedagogical activity, Zafranskaya M. M. has published more than 250 scientific papers in domestic and foreign publications.
- Author of 4 monographs, methodological and scientific manuals and developments, 13 applications for inventions (10 patents were obtained), 4 laboratory regulations for the production of various cell cultures, 8 instructions for use.
- Under the supervision of M. M. Zafranskaya, 3 PhD theses were prepared and defended, and 2 dissertation studies were carried out.
- Zafranskaya M. M. developed a methodology to assess the immunosuppressive potential of mesenchymal stem cells both in vitro and in vivo. It allowed us to determine the criteria for evaluating the immunomodulatory effect of mesenchymal stem cells. Based on the results obtained, a technology for cellular immunotherapy of multiple sclerosis was developed, taking into account a preliminary assessment of the therapeutic effectiveness of mesenchymal stem cells. The proposed immunological criteria to assess the immunosuppressive properties of mesenchymal stem cells have no analogues in world practice and domestic healthcare and have high indicators of diagnostic sensitivity and specificity in predicting the effectiveness of cellular immunotherapy.
- Zafranskaya M. M. was awarded Honorary Certificates of the Higher Attestation Commission of the Republic of Belarus (2016), the Ministry of Health of the Republic of Belarus (2014), BelMAPO for active inventive activity (2014), and International Sakharov Environmental Institute.
Career
| 1986 | Graduated from Minsk State Medical Institute |
| 1993 | Graduated from postgraduate course at the Research Institute of Maternal and Child Health of the Ministry of Health of the Republic of Belarus |
| 1994 | PhD in Medical Sciences |
| Since 1998 | Head of Immunology and Environmental Epidemiology Chair of International Sakharov Environmental Institute of BSU |
| 2001 | Associate Professor |
| 2004-2006 | She worked as a research immunologist at the Justus-Liebig University of the Institute of Clinical Chemistry and Pathobiochemistry in Giessen, Germany |
| Since 2006 | Head of the immunology group of research laboratory of BelMAPE |
List of publications
The total number of publications is 152, including 78 articles in peer-reviewed scientific publications. During the last period, 13 applications for inventions were prepared (7 patents were obtained), 7 instructions for the use of 4 laboratory regulations for the production of various stem cell cultures, 6 innovation proposals, 9 acts of implementation of scientific developments in healthcare institutions and the educational process of higher educational institutions.
Monographs
- Зафранская, М. М. Эффект мезенхимальных стволовых клеток при клеточной терапии рассеянного склероза / М. М. Зафранская, А. С. Федулов, Ю. Е. Демидчик. – Минск: Беларус. навука, 2016. – 213 с.
- Федулов, А.С. Клеточная терапия рассеянного склероза / А.С. Федулов, А.В. Борисов, М.М. Зафранская (с соавт.) // Минск: «НиктаграфиксПлюс», 2018. – 251 с.
Articles in peer-reviewed journals
- Zafranskaya, M. PGE2 contributes to in vitro MSC-mediated inhibition of non-specific- and antigen-specific T cells proliferation in MS patients / M. Zafranskaya, D. Nizheharodava, M. Yurkevich, et al. // Scand. J. Immunol. – 2013. – Vol. 78, № 5. – P. 455–462.
- Zafranskaya, M. In vitro assessment of mesenchymal stem cells immunosuppressive potential in multiple sclerosis patients / M. M. Zafranskaya, D. B. Nizheharodova, M. Y. Yurkevich et al. // Immunol. Lett. – 2013. – Vol. 149, № 1/2. – P. 9–18.
- Нижегородова, Д.Б. Возможности доклинической оценки клеточной терапии / Д.Б. Нижегородова, М.Ю. Юркевич, Т.В. Кондратович, М.М. Зафранская // Инновационные технологии в медицине. – 2017. – Т. 5, № 1–2. – С. 43–51.
- Зафранская, М.М. Мезенхимальные стволовые клетки как стратегия лечения рассеянного склероза: актуальные проблемы и перспективы / М.М. Зафранская, Д.Б. Нижегородова // Медицинская иммунология. – 2017. – Т. 19, № 6. – С. 683–704. (Россия).
- Нижегородова, Д.Б. Иммунологические механизмы нейровоспаления и нейродегенерации / Д.Б. Нижегородова, А.Н. Левковская, М.М. Зафранская // Иммунопатология, аллергология, инфектология. – 2018. – № 4. – С. 27–42.
- Зафранская, М.М. Миграция мультипотентных мезенхимальных стромальных клеток при системном и локальном введении на экспериментальной модели паркинсонизма / М.М. Зафранская, Д.Б. Нижегородова, Н.Е. Алейникова с соавт. // Анналы клинической и экспериментальной неврологии. – 2019. – №2, Том 13. – С. 32-40. (Россия).
- Boika A, Aleinikava N, Chyzhyk V, Zafranskaya M, Nizheharodava D, Ponomarev V. Mesenchymal stem cells in Parkinson’s disease: Motor and nonmotor symptoms in the early posttransplant period. Surg Neurol Int 2020;11:380.
- Зафранская, М.М. Фенотипический профиль лимфоидных клеток периферической крови пациентов с воспалительными заболеваниями кишечника / М.М. Зафранская, А.Ю. Адамович, А.В. Воробей, А.М. Старостин, Д.Б. Нижегородова // Медицинская иммунология. – 2020. – Т. 22, № 6. – С. 1131-1140.
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Sources of additional information