Cytogenetic methods for the diagnosis of systemic pathology
Key results and projects
Currently engaged in the development of fundamentally new methodological approaches in laboratory diagnostics and monitoring of cancer patients treatment using spin spectrometry. The implementation of the development made it possible to increase the early diagnosis of malignant neoplasms of the main localizations by 15%. The conducted research is summarized in the PhD’s thesis.
The main areas of research from 1999 to 2005 were the development of new high-tech methods to determine the functional state of homeostasis in cancer patients during complex and multimodal treatment with general hyperthermia and hyperglycemia; a set of measures aimed at developing a system to assess the severity of patients with the development of purulent-septic complications, volumes and methods of detoxification therapy; development of a methodology to establish metabolic disorders in the homeostasis system and individual prediction of complications in the course of complex treatment of patients with solid tumors of major localizations; research in the field of membrane-cell interactions in the malignant process.
The implementation of these areas in practice allowed us to objectively assess the functional state and avoid the development of severe complications with a diagnostic efficiency of 77.5-84.2% in the process of complex and multimodal treatment of cancer patients. The developed research directions of R. M. Smolyakova are summarized in her doctoral thesis.
With the direct participation of R. M. Smolyakova (from 2006 to 2017), for the first time in the Republic of Belarus, new high-tech areas were developed and introduced into scientific and clinical practice in the priority areas for oncology: flow cytofluorometry, molecular sequencing, fluorescent in situ hybridization, molecular cytogenetics, oncogenomics, nephelometry, which are used for differential, clarifying diagnostics and determining the treatment tactics of cancer patients in oncology institutions of the Republic.
Graduated from the Faculty of Biology of Belarusian State University
Awarded PhD in Biology
Defended doctoral thesis in Moscow, major in “Biochemistry” and “Oncology”
Associate Professor of Environmental and Molecular Genetics Chair of International Sakharov Environmental University
Awarded Associate Professor. Throughout her career, she was an employee of the Russian Research Center of OMR named after N. N. Alexandrov. Currently, she is the Head of the Republican Molecular Genetic Laboratory of Carcinogenesis of the State Institution “Republican Research and Practical Center of Oncology and Medical Radiology named after N. N. Alexandrov”
Professor of International Sakharov Environmental Institute of BSU
Head of General Ecology, Biology and Environmental Genetics Chair of International Sakharov Environmental Institute of BSU
List of publications
Immunohistochemical characteristics of molecular biological subtypes of breast cancer / I. N. Marchuk, R. M. Smolyakova, E. M. Shpadaruk, A. I. Prokopuk // Ecology. – 2019. – No. 3. – pp. 58-64
Immunohistochemical characteristics of molecular biological subtypes of breast cancer / I. N. Marchuk, R. M. Smolyakova, E. M. Shpadaruk, A. I. Prokopuk / / International State Ecological Institute named after A.D. Sakharov, Belarusian State University. Bulletin of Ecology. Minsk, 2019, No. 3, pp. 58-64.
Molecular biological assessment of adenocarcinomas from an undetected primary focus / R. M. Smolyakova / / Ecology. – 2018. – No. 4. – pp. 94-100.
Molecular genetic characteristics of drug resistance in lung cancer / Targonskaya A. A., Smolyakova R. M. / / Sakharov Readings 2017: ecological problems of the XXI century: materials of the 17th International Conference, May 18-19, 2017, Minsk, Republic of Belarus : in 2 hours / International State Ecol. Sakharov Institute of Bel. State Uni-ta; editorial board: S. E. Golovaty [et al.S. A. Maskevich, Doctor of Physical and Mathematical Sciences, professor S. S. Poznyak. Minsk, IVC Minfina Publ., 2017, part 1, pp. 232-233.