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Organic Chemistry
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Chemistry and Biochemistry of Carbohydrates
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Methods of Structural Biology in the study of protein function
- Chemical and microbiological methods for the synthesis of nucleosides and nucleotides modified in the heterocyclic base and carbohydrate fragment have been developed.
- 5′-triphosphates of 3′-fluoro-2′,3′-dideoxynucleosides were synthesized and their high efficiency in inhibiting DNA synthesis under the action of DNA polymerases was shown.
- Methods have been developed for the synthesis of the bioregulator-trimmer 2′, 5′ – oligoadenylate, which is one of the intermediates in the mechanism of antiviral action of interferon, as well as its 2′, 3′ – riboanhydro analog, which exhibits immunomodulatory properties and prevents tissue rejection in transplantation operations.
- Methods for the synthesis of selectively blocked nucleotides containing photosensitive protective groups based on thioxanthone derivatives are developed; the possibility of using the obtained compounds for constructing high-density DNA biochips is shown.
- Chemical and microbiological methods for the synthesis of nucleosides and nucleotides modified in the heterocyclic base and carbohydrate fragment have been developed.
- 5′-triphosphates of 3′-fluoro-2′,3′-dideoxynucleosides were synthesized and their high efficiency in inhibiting DNA synthesis under the action of DNA polymerases was shown.
- Methods have been developed for the synthesis of the bioregulator-trimmer 2′, 5′ – oligoadenylate, which is one of the intermediates in the mechanism of antiviral action of interferon, as well as its 2′, 3′ – riboanhydro analog, which exhibits immunomodulatory properties and prevents tissue rejection in transplantation operations.
- Methods for the synthesis of selectively blocked nucleotides containing photosensitive protective groups based on thioxanthone derivatives are developed; the possibility of using the obtained compounds for constructing high-density DNA biochips is shown.
Implementations
The patented original antiviral drug “Nucleavir” as well as the antitumor drug “Fludarabine phosphate” produced at the Minsk RUE “Belmedpreparaty”.
1968 | Graduated from the Faculty of Chemistry of BSU |
1970. | Completed the postgraduate course of BSU |
1970-1974 | Senior Engineer-Technologist, Junior Researcher at the Institute of Physical and Organic Chemistry of the Academy of Sciences of the BSSR |
1974-1997 | Junior Researcher, Chief Researcher at the Institute of Bioorganic Chemistry of the National Academy of Sciences |
1975 | PhD in Chemistry |
1980 | Internship at the Central Institute of Molecular Biology of the GDR Academy of Sciences and the Faculty of Chemistry of Humbold University (Berlin, GDR) |
1981 | Scholar of the German Research Society (Constance, Germany) |
1994 | Doctor in Chemistry |
1997-2000 | Researcher at the Faculty of Chemistry of the Elite University of Constance, Germany |
2000-2005 | Leading specialist of NIGU-Chemie, Chemogenix, Nimblegen (Germany) |
Since 2006 | Professor of Environmental Chemistry and Biochemistry Chair of International Sakharov Environmental Institute of Belarusian State University |
He has more than 120 scientific papers, including more than 40 publications in English, 3 textbooks, 44 USSR Copyright certificates for inventions, 7 patents (USA, GDR, FRG, Republic of Belarus and Eurasian patent):
- Z.G. Chedgeavadze, A.V. Skamrov, R.Sh. Beabealashivilli, E.I. Kvasyuk, G.V. Zaitseva, I.A. Mikhailopulo, G. Kowollik, P. Langen. 3′-Fluoro-2′,3′-dideoxy-β-D-erythro-pentofuranosylnucleoside 5′-triphosphates – terminators of DNA synthesis, catalyzed by DNA Polymerases // FEBS Letteers. 1985. V. 183, №. 2, 275-278.
- E.I. Kvasyuk, T.I. Kulak, N.B. Khripach, I.A. Mikhailopulo, E. Uhlmann, R. Charubala, W. Pfleiderer. Nucleotides XXIV. Preparative synthesis of trimeric (2′-5′) oigoadenylic acid // Synthesis. 1987, №6, 535541.
- 3. A.I. Zinchenko, V.N. Barai, S.B. Bokut, E.I. Kvasyuk, I.A. Mikhailopulo. Synthesis of 9-(β-D-arabinofuranosyl)guanine using whole cells of Escherichia coli // Appl. Microbiol. Biotechnol. 1990. V. 32, №3, 658-661.
- I.A. Mikhailopulo, N.E. Poopeiko, T.I. Prikota, G.G. Sivets, E.I. Kvasyuk, J. Balzarini, E. DeClercq. Synthesis and antiviral and cytostatic properties of 3′-deoxy-3′-fluoro-and 2′-azido-3’fluoro-2′,3′-dideoxy-D-ribofuranosids of natural heterocyclic bases // J. Med. Chem. 1991. V. 34, №7, 2195-2202.
- E.I. Kvasyuk, T.I. Kulak, I.A. Mikhailopulo, R. Charubala, W. Pfleiderer. Nucleotides. Part XLV. Synthesis of new (2′-5′) Adenylate Trimers, containing 5’Amino-5′-deoxyadenosine Residues at the 5′-End of the Oligoadedenylate chain, and Its Analogues, Carrying a 9[(2-Hydroxy-ethoxy)methyl]adenine Residue at the 2′-Terminus // Helv. Chim Acta. 1995. V. 78, №5, 1777-1784.
- E.I. Kvasyuk, T.I. Kulak, O.V. Tkachenko, S.L. Sentyureva, I.A. Mikhailopulo, R.J. Suhadolnik, E.E. Henderson, S.E. Horvath, Ming-Xu Guan, W. Pfleiderer. Synthesis and biological activity of new sugar modified 2′,5′-oligoadenylate trimers // Nucleosides and Nucleotides. 1997. V. 16, № 5/6, 773-776.
- H. Giegrich, S. Eilese-Bühler, Chr. Hermann, E.I. Kvasyuk, R. Charubala, W. Pfleiderer. New Photolabile Protecting groups in nucleoside and nucleotide chemistry-synthesis, cleavage mechanisms and applications // Nucleosides and Nucleotides. 1998. V.17, № 9/11, 1987-1996
- C. Hermann, E. Kvassiouk, W. Pfleiderer. Nucleotides Part LXXIX. New building blocks for photolithographic synthesis of oligonucleotides // Helv. Chim. Acta. 2011. V. 94, № 3, 362-370.
- A.S. Drazdou, A.N. Sobchuk, V.E. Syakhovich, O.S. Bokut, E.I. Kvasyuk, B.A. Bushuk, S.B. Bokut. Fluorescence decay time distribution of 1-anilinonaphthalene-8-sulfonate in human oxyhemoglobin A1b solution // J. Appl. Spectrosc. 2012. V. 79, № 3, 437-445.
- А.И. Береснев, Е.И. Квасюк, С.В. Квач, А.И. Зинченко. Атака на теломеры, или Подход к терапии рака с помощью 6-тио-2’-дезоксигуанозина // Наука и инновации. 2016. № 9 (163). 58-61.
- А.И. Береснев, А.Н. Рымко, Л.А. Ерошевская, С.В. Квач, Е.И. Квасюк, А.И. Зинченко. Синтез флударабин-5′-монофосфата с использованием бактериальных рекомбинантных ферментов // Весцi Нацыянальнай акадэмii навук Беларусi. Серыя бiялагiчных навук. 2017. № 1. С. 7-15.
- А.И. Береснев, Е.И. Квасюк, А.И. Зинченко. Синтез 2’-дезоксиизогуанозина с использованием бактериальнвх нуклеозидфосфорилаз // Микробные биотехнологии: фундаментальные и прикладные аспекты: сб. науч. тр. / Институт микробиологии НАН Беларуси; под ред.: Э.И. Коломиец и А.Г. Лобанка. – Минск: Беларуская навука. 2018. Т. 10. С. 299-305.
- М.В. Лисовская, Е.И. Квасюк. Синтез эфиров эмоксипина // Журн. Белорус. гос. ун-та. Экология. 2018. № 4. С. 119-127.